Attaching Biochemical Information on Putative Enzymatic Reactions

A cellular system is composed of a considerable number of elements including genes, proteins or enzymes, and metabolites. They are dynamically connected and interdependent to construct a network diagram, which is referred to as a metabolic pathway. The significance of a systems approach has been recognized for understanding the activities of living organisms (Eisenberg et al., 2000; Kanehisa, 2001; Kanehisa & Bork, 2003). Among the elements mentioned above, genetic information has been studied from a holistic viewpoint since the late 1990s. Whole genome sequencing projects have uncovered the genomic aspects of biological substances, i.e., the repertoire of genes and their products encoded on each genome, generating an exhaustive encyclopedia containing macromolecules such as DNA, RNA and proteins. The information of molecular interactions like metabolic pathways and regulatory systems has also been compiled from text-based literature and stored in several computer dataAbsTRACT